Multicellular Tumour Spheroids in a Translational PET Imaging Strategy

نویسنده

  • AZITA MONAZZAM
چکیده

@ 0///)// ! 115 $8$68 8 145 "!36"$6768""6! ######63$"8 (BLOCKIN#AA+9+++AAAABC######63$"8* When you leave your homeland, you leave a part of your heart there. It needs many big hearts to repair it. I have been blessed to have so many warm hearted people around me to complete my lost piece of heart. To my beloved husband Pasha and my precious son Attila List of enclosed papers This thesis is based on the following articles and manuscripts, which will be referred to in the body text by their Roman numerals I-V. A new, fast and semi-automated size determination method (SASDM) for studying multicel-lular tumor spheroids " Application of the multicellular tumour spheroid model to screen PET tracers for analysis of early response of chemotherapy in breast cancer " Breast Cancer Res. Tumour Spheroid as a model for evaluation of [ 18 F]FDG as biomarker for cancer treatment monitoring, " Patent , PH0515b, (2006). Application of Multicellular tumour spheroid model to screen PET-tracers to monitor early response of che-motherapy in cancer, " Patent, PH0515c, (2006).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

In vivo imaging of cellular proliferation in renal cell carcinoma using 18F-fluorothymidine PET

Objective(s): The ability to measure cellular proliferation non-invasively in renal cell carcinoma may allow prediction of tumour aggressiveness and response to therapy. The aim of this study was to evaluate the uptake of 18Ffluorothymidine (FLT) PET in renal cell carcinoma (RCC), and to compare this to 18F-fluorodeoxyglucose (FDG), and to an immunohistochemical measure of cellular proliferatio...

متن کامل

Comparing PET metabolic parameters with clinicopathological factors in predicting onset of early recurrence in recently diagnosed hepatocellular carcinoma

Introduction: Early recurrence of hepatocellular carcinoma (HCC) is a major risk factor affecting survival even after hepatectomy. Many clinical, biochemical parameters and pathological grading like fibrosis 1 index have been used for risk stratifying HCC. However not many studies have combined all of them. It is therefore important to risk stratify HCC especially with newer PE...

متن کامل

Emulsion technologies for multicellular tumour spheroid radiation assays.

A major limitation with current in vitro technologies for testing anti-cancer therapies at the pre-clinical level is the use of 2D cell culture models which provide a poor reflection of the tumour physiology in vivo. Three dimensional cell culture models, such as the multicellular spheroid, provide instead a more accurate representation. However, existing spheroid-based assessment methods are g...

متن کامل

Modes of Cell Death Induced by Photodynamic Therapy Using Zinc Phthalocyanine in Lung Cancer Cells Grown as a Monolayer and Three-Dimensional Multicellular Spheroids.

Photodynamic therapy (PDT) involves interaction of a photosensitizer, light, and molecular oxygen which produces singlet oxygen and subsequent tumour eradication. The development of second generation photosensitizers, such as phthalocyanines, has improved this technology. Customary monolayer cell culture techniques are, unfortunately, too simple to replicate treatment effects in vivo. Multicell...

متن کامل

Optical properties of multicellular tumour spheroids.

Multicellular tumour spheroids grown in vitro have been widely used in cancer research as an experimental preparation with many of the characteristics of tumours. They provide a model system for understanding the optical behaviour of tumour tissue, which is of interest in novel diagnostic and therapeutic procedures. Optical measurements on fresh spheroids in the wavelength range of 600-1000 nm ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2007